Study Finds Rise In Overdoses From Opioids In Diarrhea Drug

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A Rutgers study has uncovered a new threat in the opiate epidemic: Overdoses of loperamide, an over-the-counter diarrhea medication, have been steadily increasing in number and severity nationwide over five years.

Misuse of the drug is particularly alarming because non-prescription drugs like loperamide are inexpensive, readily available online and in retail stores, undetectable on routine drug tests and can be bought in large quantities at one time.

The study, published in the journal Clinical Toxicology, found increasing instances in which patients with opioid use disorder misused loperamide to prevent or self-treat withdrawal symptoms. To a lesser extent, some took massive doses to get a high similar to heroin, fentanyl or oxycodone.

The researchers reviewed cases of patients with loperamide exposure reported by medical toxicologists to a national registry, the Toxicology Investigators’ Consortium, from January 2010 to December 2016, reporting a growing number of cases over that time frame. The Poison Control Center database (National Poison Data System) also reported a 91 percent increase during that time period, which in 2015 included 916 exposures and two deaths.

The patients reporting misuse in the Rutgers study were predominantly young Caucasian men and women. The majority used extremely high doses of loperamide, the equivalent of 50 to 100 two-milligram pills per day.

“Possible ways of restricting loperamide misuse include limiting the daily or monthly amount an individual could purchase, requiring retailers to keep personal information about customers, requiring photo identification for purchase and placing medication behind the counter,” she said. “Most importantly, consumers need to understand the very real danger of taking this medication in excessive doses.”

Medical Express

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